Intraventricular Pressure Gradients in Heart Failure

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Guerra, M (Author) Other; Bras Silva, C (Author) FMUP; Amorim, MJ (Author) Other; Moura, C (Author) Other; Bastos, P (Author) Other; Leite Moreira, AF (Author) Other

Journal

Title: Physiological Research

Vol. 62 No. 5

Pages: 479-487

ISSN: 0862-8408

Publisher: Akademie Ved Ceske Republiky

Indexing

ISI Web of Knowledge - 12 Citations

ISI Web of Science

Scopus - 15 Citations

Pubmed / Medline

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-008-HV6

Abstract (EN): The aim of the present study was to characterize intraventricular pressure gradients (IVPGs) in an animal model of chronic heart failure. New Zealand rabbits were treated with doxorubicin (heart failure group, n=5) or saline (control group, n=5) and instrumented with pressure catheters placed in the apex and outflow-tract of left ventricle (LV) and with sonomicrometer crystals placed in the apex and base of the LV free wall. In heart failure animals, ventricular filling was delayed and slower when compared with control animals. Moreover, the physiological nonuniformity observed between apical and basal segments in normal hearts was abolished in failing hearts. Simultaneously, physiological IVPGs observed during normal ventricular filling were entirely lost in heart failure animals. During ventricular emptying physiological nonuniformity between apical and basal segments observed in control animals was also abolished in heart failure animals. In failing hearts minimal length occurred later and almost at same time both in apical and in basal myocardial segments. Simultaneously, the characteristic IVPG pattern observed in healthy hearts during systole, which promotes ventricular emptying, was not observed in failing hearts. The present study showed that diastolic IVPGs, a marker of normal ventricular filling, and systolic IVPGs, a marker of normal ventricular emptying, are abolished in heart failure.

Language: English

Type (Professor's evaluation): Scientific

Notes: <a href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord&KeyUT=000327444700002">Indexado na ISI Web of Science</a>

No. of pages: 9