Response of jejunal Na+,K+-ATPase to 5-hydroxytryptamine in young and adult rats: Effect of fasting and refeeding

• Type: Article in International Scientific Journal
• Date: 2000

Authors

Lucas Teixeira, V (Author) Other; Maria Paula Serrão (Author) FMUP; soares-da-silva, p (Author) FMUP

Journal

Title: Acta Physiologica Scandinavica

Vol. 169

Pages: 167-172

ISSN: 0001-6772

Publisher: Blackwell

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-000-ZRN

DOI: 10.1046/j.1365-201x.2000.00721.x

Abstract (EN): The present study is aimed to evaluate the effects of 5-hydroxytryptamine (5-HT) upon jejunal Na+, K+-ATPase in young (20-day-old) and adult (60-day-old) rats, and determine the effect of food intake on the response of the sodium pump to the amine. Basal Na+, K+-ATPase activity in jejunal epithelial cells from young rats was twice that in adult animals and responded to 5-HT with stimulation. In adult rats, fasting reduced by 25% basal jejunal Na+,K+-ATPase activity, whereas in young rats, no such change was observed. The sensitivity of jejunal Na+,K+-ATPase to 5-HT in young fasted rats was similar to that observed in fed animals. The effect of refeeding in young rats was a 2-fold increase in jejunal Na+, K+-ATPase activity, this being accompanied by insensitivity to 5-HT. In adult rats, refeeding was accompanied by an increase in jejunal Na+,K+-ATPase activity. It is concluded that the stimulatory effect of 5-HT upon jejunal Na+,K+-ATPase activity is a phenomenon dependent on both age and type of diet. In young rats, it is the food intake that plays an important role in development of insensitivity of Na+,K+-ATPase to stimulation by 5-HT, while in adult animals fasting or fasting followed by refeeding does not play a major role in regulating its sensitivity to the amine.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6