Altered dopaminergic transmission in the anorexic anx/anx mouse striatum

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Johansen, JE (Author) Other; Teixeira, VL (Author) Other; Johansson, C (Author) Other; Maria Paula Serrão (Author) FMUP; Berggren, PO (Author) Other; soares-da-silva, p (Author) FMUP; Schalling, M (Author) Other; Bertorello, AM (Author) Other

Journal

Title: NeuroReport

Vol. 12

Pages: 2737-2741

ISSN: 0959-4965

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-000-TJE

DOI: 10.1097/00001756-200108280-00029

Abstract (EN): We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However, addition of dopamine in vitro failed to suppress the increased activity in anx/anx striatal neurons. Striatal dopamine and its metabolites, but not norepinephrine, were slightly but significantly lower in anx/anx mice than in normal littermates. We suggest that abnormal dopaminergic transmission may contribute to the anx phenotype. NeuroReport 12:2737-2741 (C) 2001 Lippincott Williams & Wilkins.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5