Lidocaine prevents noxious excitation of bladder afferents induced by intravesical capsaicin without interfering with the ensuing sensory desensitization: An experimental study in the rat

• Type: Article in International Scientific Journal
• Date: 1998

Authors

António Avelino Silva (Author) FMUP; Francisco Cruz (Author) FMUP; Coimbra, A (Author) Other

Journal

Title: Journal of Urology

Vol. 159

Pages: 567-570

ISSN: 0022-5347

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 23 Citations

Other information

Authenticus ID: P-001-8KY

DOI: 10.1016/s0022-5347(01)63985-5

Abstract (EN): Purpose: The effects of the local anesthetic lidocaine on the noxious excitation and subsequent desensitization of bladder sensory fibers, produced by intravesical capsaicin, were evaluated through c-fos activation in the spinal cord. Materials and Methods: Noxious excitation was demonstrated by counting Fos-immunoreactive (IR) cells occurring in the rat spinal cord 2 hours after intravesical administration of 1 mM. capsaicin, preceded or not by 2% lidocaine. Desensitization was studied by comparing the number of Fos-IR cells induced by 1% acetic acid in rats treated 24 hours before with 1 mM. intravesical capsaicin preceded or not by 2% lidocaine. Results: Lidocaine instilled previously markedly reduced the number of Fos-IR spinal cells responding to capsaicin-induced bladder afferent excitation. Numbers of Fos-IR cells induced by acetic acid instillation in bladders desensitized by capsaicin administrated 24 hours before were not changed by lidocaine application prior to capsaicin. Conclusions: These findings suggest that local anesthetic pretreatment of the bladder with lidocaine reduces the capsaicin-induced noxious excitation of the sensory fibers without decreasing their subsequent desensitization.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4