Hereditary gastrointestinal cancers: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Stjepanovic, N (Author) Other; Moreira, L (Author) Other; Carneiro F (Author) FMUP; Balaguer, F (Author) Other; Cervantes, A (Author) Other; Balmana, J (Author) Other; Martinelli, E (Author) Other

Journal

Title: Annals of Oncology

Vol. 30

Pages: 1558-1571

ISSN: 0923-7534

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 56 Citations

Scopus - 67 Citations

Other information

Authenticus ID: P-00R-C1E

DOI: 10.1093/annonc/mdz233

Abstract (EN): Knowledge of genetic susceptibility to gastrointestinal cancers is constantly evolving with identification of new genes. Similarly, a better understanding of the genotype/phenotype relationship in patients with Lynch syndrome (LS) or familial adenomatous polyposis (FAP) is leading to more individualised surveillance recommendations. In addition, molecular profiling of patients with cancer has been shown to guide targeted therapies, such as immunotherapy. Specialists involved in the care of patients with gastrointestinal cancer should be familiar with the main hereditary cancer syndromes and refer patients to specialised cancer genetic units for adequate genetic counselling and to address specific concerns associated to each genetic susceptibility. These guidelines aim to summarise the evidence-based data on hereditary colorectal cancer (CRC), gastric cancer (GC) and pancreatic cancer (PC) and provide useful clinical recommendations for identification and management of patients with hereditary gastrointestinal cancers.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14