Cord blood levels of IL-6, IL-8 and IL-10 may be early predictors of bronchopulmonary dysplasia in preterm newborns small for gestational age

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Rocha, G (Author) Other; Proenca, E (Author) Other; Guedes, A (Author) Other; Carvalho, C (Author) Other; Areias, A (Author) Other; Ramos, JP (Author) Other; Rodrigues, T (Author) FMUP; Guimarães H (Author) FMUP

Journal

Title: Disease Markers

Vol. 33

Pages: 51-60

ISSN: 0278-0240

Publisher: Hindawi

Indexing

ISI Web of Knowledge - 34 Citations

Scopus - 37 Citations

Other information

Authenticus ID: P-002-G8E

DOI: 10.3233/dma-2012-0903

Abstract (EN): Introduction: Various cytokines have been associated to the occurrence of bronchopulmonary dysplasia (BPD) in preterm neonates. AIM: To establish an association between cord blood cytokines and BPD, so that they could be used, in clinical practice, as early markers of BPD. Material and methods: Preterms less than 30 weeks gestational age, were analysed by ELISA microassay for venous cord blood IL-1 beta, IL-6, IL-8, TNF-alpha and IL-10, and compared between the BPD and non-BPD groups. Results: One hundred and fifty neonates completed the study; 31 (21%) small for gestational age (SGA); 16 were deceased before 28 days of life; 36 developed mild BPD and 20 developed moderate/severe BPD. Elevated cord blood IL-8 was associated with death or moderate/severe BPD. SGA patients with moderate/severe BPD presented higher cord blood values of IL-8, lower IL-6 and IL-10 when compared with SGA without moderate/severe BPD; and higher IL-8 levels when compared with patients without moderate/severe BPD. Conclusion: These results support an association between cord blood IL-8 and moderate/severe BPD, independently of the intra-uterine growth; and the association of cord blood IL-6 and IL-10 and moderate/severe BPD in SGA preterm newborns.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10