Improving TCI control for the automatic delivery of rocuronium

• Type: Article in International Conference Proceedings Book
• Date: 2020

Authors

Jorge Miguel P. P. Silva (Author) FEUP; Teresa Mendonça (Author) Other; Paula Rocha (Author) FEUP

Conference proceedings International

Title: 2020 28th Mediterranean Conference on Control and Automation (MED)

Pages: 905-908

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Other information

Authenticus ID: P-00S-Q3V

DOI: 10.1109/med48518.2020.9183212

Abstract (EN): The contribution of this paper is to present a state-feedback design method for the automatic control of the Neuromuscular Blockade Level (NMB) based on pole placement scheme. The typical clinical procedure in surgery room begins by the administration of an initial bolus in order to enable a fast intubation, followed by a piecewise constant infusion of a certain neuromuscular relaxant (here, rocuronium). This latter procedure, known as TCI (Target Controlled Infusion) aims at reaching and maintaining a desired level for the NMB. First, the identification of the parameters of a PPM (parameter parsimonious model) is performed using the bolus response until the NMB reaches the target NMB level. Thereafter, the controller is tuned according to the identified patient parameters, in order to suitably place the poles, leading to an individualized target control infusion. The pole placement criterion is based on a weighted cost function that takes into account both the tracking performance and the average administered drug dose. The obtained results are illustrated by means of simulations. © 2020 IEEE.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4