Nerve Growth Factor mediates its pro-invasive effect in parallel with the release of a soluble E-cadherin fragment from breast cancer MCF-7/AZ cells

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Dolle, L (Author) Other; Oliveira, MJ (Author) Other; Bruyneel, E (Author) Other; Hondermarck, H (Author) Other; Bracke, M (Author) Other

Journal

Title: Journal of Dairy Research

Vol. 72

Pages: 20-26

ISSN: 0022-0299

Publisher: Cambridge University Press

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-000-61V

DOI: 10.1017/s0022029905001160

Abstract (EN): To define better the function of Nerve Growth Factor (NGF) in breast cancer progression, we investigated whether this polypeptide was able to induce breast cancer cell invasion. NGF inhibited aggregation of tumour cells through modulation of the E-cadherin/catenin complex function. In addition, NGF induced the breast cancer cells to invade into Matrigel. We focused our attention on how NGF prevents aggregation, in order to discover the signalling pathway that leads tumour cells to acquire the invasive phenotype. Moreover, studies on the identification of signalling pathways that are responsive for NGF-induced invasion will be basically described.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7