Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Lara Guerreiro, JRL (Author) Other; Bochenkov, VE (Author) Other; Runager, K (Author) Other; Aslan, H (Author) Other; Dong, MD (Author) Other; Enghild, JJ (Author) Other; Victor de Freitas (Author) FCUP; Ferreira Sales, MGF (Author) Other; Sutherland, DS (Author) Other

Journal

Title: ACS Sensors

Vol. 1

Pages: 258-264

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 29 Citations

Scopus - 33 Citations

Other information

Authenticus ID: P-00M-5C8

DOI: 10.1021/acssensors.5b00054

Abstract (EN): Molecular imprinting polymers (MIP) have been applied to capture and stabilize complex protein matrices at plasmonic sensor surfaces. Ultrathin MIP layers at the surface of gold nanodisks enable the label free quantification of global interactions of polyphenols with protein mixtures. Separate polyphenols (catechin, procyanidin B3- catechin dimer, and PGG-pentagalloyl glucose) give specific and different binding levels to the MIP supported saliva plasmonic sensor. The demonstrated biosensor has application to study bioavailability of polyphenols or evaluation of local retention of small drug molecules.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7