Synthesis and Antibacterial Activity of Ionic Liquids and Organic Salts Based on Penicillin G and Amoxicillin hydrolysate Derivatives against Resistant Bacteria

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Ferraz, R (Author) Other; Silva, D (Author) Other; Dias, AR (Author) Other; Dias, V (Author) Other; Santos, MM (Author) FCUP; Pinheiro, L (Author) Other; Prudencio, C (Author) Other; Noronha, JP (Author) Other; Petrovski, Z (Author) Other; Branco, LC (Author) Other

Journal

Title: Pharmaceutics

Vol. 12

Final page: 221

ISSN: 1999-4923

Publisher: MDPI

Indexing

ISI Web of Knowledge - 56 Citations

Scopus - 61 Citations

Other information

Authenticus ID: P-00R-VER

DOI: 10.3390/pharmaceutics12030221

Abstract (EN): The preparation and characterization of ionic liquids and organic salts (OSILs) that contain anionic penicillin G [secoPen] and amoxicillin [seco-Amx] hydrolysate derivatives and their in vitro antibacterial activity against sensitive and resistant Escherichia coli and Staphylococcus aureus strains is reported. Eleven hydrolyzed beta-lactam-OSILs were obtained after precipitation in moderate-to-high yields via the neutralization of the basic ammonia buffer of antibiotics with different cation hydroxide salts. The obtained minimum inhibitory concentration (MIC) data of the prepared compounds showed a relative decrease of the inhibitory concentrations (RDIC) in the order of 100 in the case of [C2OHMIM][seco-Pen] against sensitive S. aureus ATCC25923 and, most strikingly, higher than 1000 with [C(16)Pyr][seco-Amx] against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. These outstanding in vitro results showcase that a straightforward transformation of standard antibiotics into hydrolyzed organic salts can dramatically change the pharmaceutical activity of a drug, including giving rise to potent formulations of antibiotics against deadly bacteria strains.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 23