Breast Metastasis From a Combined Hepatocellular-Cholangiocarcinoma

• Type: Article in International Scientific Journal
• Date: 2019

Authors

sousa, m (Author) ICBAS; Coelho, R (Author) Other; Rios, E (Author) Other; Gomes, S (Author) Other; Carneiro F (Author) FMUP; Macedo G (Author) FMUP

Journal

Title: ACG Case Reports Journal

Vol. 6

ISSN: 2326-3253

Publisher: American College of Gastroenterology

Indexing

ISI Web of Knowledge - 1 Citation

Other information

Authenticus ID: P-00Q-W52

DOI: 10.14309/crj.0000000000000057

Abstract (EN): Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a unique entity that contains mixed elements of both hepatocellular carcinoma and cholangiocarcinoma. We report a 62-year-old woman with alcoholic cirrhosis with elevated alpha-fetoprotein of 25.3 ng/mL. Abdominal computed tomography showed a poorly defined subcapsular nodular lesion in the VIII segment, showing enhancement during the arterial phase and washout in the delayed phase. Histological examination of hepatic segmentectomy revealed a malignant epithelial neoplasia constituted by 2 distinct components, consistent with the diagnosis of cHCC-CC, classical type. One year after surgical resection, the patient noticed a nodule in the right breast. Histological examination of core needle biopsy was compatible with a metastasis in the breast of the previously diagnosed liver cancer. To our knowledge, this is the first report of breast metastases from a cHCC-CC, denoting disseminated metastatic disease and poor prognosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4