Modulation of Leptin and Leptin Receptor Expression in Mice Acutely Infected with Neospora caninum

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Teixeira, L (Author) ICBAS; Alexandra Correia (Author) ICBAS; Oliveira, BM (Author) Other; Pinto, A (Author) Other; ferreira, pg (Author) ICBAS; Manuel Vilanova (Author) ICBAS

Journal

Title: Pathogens

Vol. 9

Pages: 1-16

Publisher: MDPI

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 3 Citations

Associated Projects

ADIPONEO - Estudo da resposta imunológica no tecido adiposo de hospedeiros infectados com Neospora Caninum

Other information

Authenticus ID: P-00S-FY0

DOI: 10.3390/pathogens9070587

Abstract (EN): Neospora caninumis an apicomplexan parasite that in cattle assumes particular importance, as it is responsible for abortions reported worldwide. Leptin is an adipokine mainly secreted by adipocytes, which beside its role in maintaining metabolic homeostasis also has important effects in both innate and adaptive immunity. In previous work, we showed that mice chronically infected withN. caninumhad elevated serum leptin levels. Here, we sought to assess whether acute infection withN. caninuminfection influenced the production of this adipokine as well as leptin receptor mRNA levels. Our results show that acute infection withN. caninumled to decreased leptin serum levels and mRNA expression in adipose tissue. A decrease in leptin receptor transcript variant 1 mRNA (long isoform) and leptin receptor transcript variant 3 mRNA (one of the short isoforms) expression was also observed. An increase in the number of cells staining positive for leptin in the liver of infected mice was observed, although this increase was less marked in Interleukin (IL)-12/IL-23 p40-deficient mice. Overall, our results show thatN. caninuminfection also influences leptin production during acute infection.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14