Spatiotemporal Control of Forkhead Binding to DNA Regulates the Meiotic Gene Expression Program

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Alves Rodrigues, I (Author) Other; Ferreira, PG (Author) Other; Moldon, A (Author) Other; Vivancos, AP (Author) Other; Hidalgo, E (Author) Other; Guigo, R (Author) Other; Ayte, J (Author) Other

Journal

Title: Cell Reports

Vol. 14

Pages: 885-895

ISSN: 2211-1247

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 9 Citations

Scientific classification

CORDIS: Natural sciences > Biological sciences > Biology > Computational biology ; Natural sciences > Biological sciences > Biology > Molecular biology

FOS: Natural sciences > Biological sciences ; Natural sciences > Computer and information sciences

Other information

Authenticus ID: P-00K-4MC

DOI: 10.1016/j.celrep.2015.12.074

Abstract (EN): Meiosis is a differentiated program of the cell cycle that is characterized by high levels of recombination followed by two nuclear divisions. In fission yeast, the genetic program during meiosis is regulated at multiple levels, including transcription, mRNA stabilization, and splicing. Mei4 is a forkhead transcription factor that controls the expression of mid-meiotic genes. Here, we describe that Fkh2, another forkhead transcription factor that is essential for mitotic cell-cycle progression, also plays a pivotal role in the control of meiosis. Fkh2 binding preexists in most Mei4-dependent genes, inhibiting their expression. During meiosis, Fkh2 is phosphorylated in a CDK/Cig2-dependent manner, decreasing its affinity for DNA, which creates a window of opportunity for Mei4 binding to its target genes. We propose that Fkh2 serves as a placeholder until the later appearance of Mei4 with a higher affinity for DNA that induces the expression of a subset of meiotic genes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11