Antepartum fetal cerebral hemorrhage not predicted by current surveillance methods in cholestasis of pregnancy

• Type: Article in International Scientific Journal
• Date: 1997

Authors

Matos, A (Author) Other; Joao Bernardes (Author) FMUP; AyresdeCampos, D (Author) Other; Patricio, B (Author) Other

Journal

Title: Obstetrics and Gynecology

Vol. 89

Pages: 803-804

ISSN: 0029-7844

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 19 Citations

Other information

Authenticus ID: P-001-BJ7

DOI: 10.1016/s0029-7844(97)00042-2

Abstract (EN): Background: The reason for increased fetal mortality in cholestasis of pregnancy is not completely understood. Intracerebral hemorrhage due to coagulation disorders, similar to those reported in the mother, is a possible explanation. Case: Antepartum fetal death occurred at 37 weeks in a primigravida with cholestasis of pregnancy. The woman was taking no medication. Autopsy revealed extensive cerebral hemorrhage. A cardiotocogram and biophysical profile performed 24 hours and 5 days, respectively, before fetal death had been normal. Conclusion: Antepartum fetal death may occur in patients with mild cholestasis who are taking no medication. Intracerebral hemorrhage is a possible cause, and this may be unpredictable with current methods of fetal surveillance. This possibility constitutes an argument in support of delivering these pregnancies as soon as lung maturity is achieved. (C) 1997 by The American College of Obstetricians and Gynecologists.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 2