Listeria infection in patients on anti-TNF treatment: Report of two cases and review of the literature

• Type: Another Publication in an International Scientific Journal
• Date: 2013

Authors

Abreu, C (Author) FMUP; Magro F (Author) FMUP; Vitas Boas, F (Author) Other; Lopes, S (Author) Other; Macedo G (Author) FMUP; Sarmento A (Author) FMUP

Journal

Title: Journal of Crohn's and Colitis

Vol. 7

Pages: 175-182

ISSN: 1873-9946

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 86 Citations

Scopus - 50 Citations

Other information

Authenticus ID: P-002-09S

DOI: 10.1016/j.crohns.2012.04.018

Abstract (EN): Listeria monocytogenes is an aerobic gram positive intracellular bacillus, predominantly affecting pregnant women, immunocompromised patients and old individuals. Invasive listeriosis, meningitis and meningoencephalitis, bacteraemia with or without joint, eye or heart focalization are clinical manifestations of the disease. Anti-TNF-alpha drugs blocking the hosts response against various microorganisms, particularly intracellular agents like Listeria monocytogenes, increase the risk of disease. We report two cases of L. monocytogenes meningitis in ulcerative colitis patients under infliximab plus steroids. One patient is HIV-1 infected. A review of reported invasive listeriosis cases under anti-TNF drugs is also showed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8