An antecedent of the MHC-linked genomic region in amphioxus

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Filipe F C Castro (Author) Other; Furlong, RF (Author) Other; Holland, PWH (Author) Other

Journal

Title: Immunogenetics

Vol. 55

Pages: 782-784

ISSN: 0093-7711

Publisher: Springer Nature

Indexing

Scopus - 34 Citations

Other information

Authenticus ID: P-009-0AJ

DOI: 10.1007/s00251-004-0642-9

Abstract (EN): The MHC genes on human chromosome 6 are located within one of the best-characterised paralogy regions of the human genome. Numerous genes mapping around this location, 6p21, have paralogues at one, two or three other chromosomal locations on HSA 1, 9 and 19. The similarity between these four chromosomal regions suggests the linkages may have adaptive significance, and/ or they may be echoes of segmental or genome duplication in human ancestry. Here, we show that six amphioxus cosmids, containing genes orthologous to those from the human MHC-linked paralogy regions, map to a single amphioxus chromosome. The composition of the MHC-linked genomic region, therefore, pre-dates vertebrate origins.

Language: English

Type (Professor's evaluation): Scientific