Nonlinear adaptive control of the NeuroMuscular Blockade in anesthesia

• Type: Article in International Conference Proceedings Book
• Date: 2011

Authors

da Silva, MM (Author) Other; Mendonca, T (Author) FCUP; Wigren, T (Author) Other

Conference proceedings International

Title: 2011 50TH IEEE CONFERENCE ON DECISION AND CONTROL AND EUROPEAN CONTROL CONFERENCE (CDC-ECC)

Pages: 41-46

50th IEEE Conference of Decision and Control (CDC)/European Control Conference (ECC)

Orlando, FL, DEC 12-15, 2011

Indexing

ISI Web of Knowledge - 5 Citations

Other information

Authenticus ID: P-002-WDN

Abstract (EN): This paper presents a nonlinear adaptive control strategy based on the Wiener model for control of the NeuroMuscular Blockade in anesthesia. The structure combines the inversion of the static nonlinearity present in the Wiener model with a pole-placement controller for the linearized system. The overall strategy exploits identification of a minimally parameterized model for the description of the effect of the muscle relaxant atracurium in the NeuroMuscular Blockade. An Extended Kalman Filter was developed for that purpose, providing estimates of the model parameters for both the linear controller and the blocks where the inversion of the static linearity is performed. Simulations were run in a database of 100 patients simulated with the standard physiologically-based pharmacokinetic/pharmacodynamic model for the NeuroMuscular Blockade. The results show that the nonlinear adaptive controller performs well regarding reference following and tackles changes in the patient's dynamics. Noisy scenarios were also simulated to test the robustness of the proposed strategy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6