Soluble interleukin 2 receptor and interleukin 1 alpha in toxic epidermal necrolysis - A comparative analysis of serum and blister fluid samples

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Correia, O (Author) Other; Delgado, L (Author) FMUP; Roujeau, JC (Author) Other; Le Cleach, L (Author) Other; Fleming Torrinha, JA (Author) Other

Journal

Title: Archives of Dermatology

Vol. 138

Pages: 29-32

ISSN: 0003-987X

Publisher: American Medical Association

Indexing

ISI Web of Knowledge - 34 Citations

Scopus - 48 Citations

Other information

Authenticus ID: P-000-QW1

DOI: 10.1001/archderm.138.1.29

Abstract (EN): Background: Toxic epidermal necrolysis (TEN) is a rare but severe adverse drug disease, characterized by extensive skin and mucosal detachment with participation of different immunoinflammatory pathways, in particular with early participation of activated CD8(+) T lymphocytes. Objective: To further study the potential role of T lymphocytes in the early phase of keratinocyte necrosis. Design: Prospective study. Setting: University hospitals. Patients: Thirteen patients with clinical and histopathologic criteria of TEN and 6 patients with second-degree burns. Main Outcome Measures: Measurement of soluble interleukin (IL) 2 receptor (sIL-2R) and IL-1alpha in serum samples and fluid of recent blisters. Results: In the blister fluid of patients with TEN, we found significantly higher levels of sIL-2R than in patients with burns, whereas IL-1alpha levels were higher in the blister fluid of burned patients. No significant differences were found in serum samples of patients with TEN and burns, in either sIL-2R or IL-1alpha. In TEN we also found significantly higher levels of sIL-2R in the blister fluid compared with serum samples, pointing to a predominantly local production contrasting with the low concentration of sIL-2R in the blister fluid of burned patients. Conclusions: Our findings of elevated sIL-2R levels in blister fluid of patients with TEN are probably related to a local down-regulation of an immunologically mediated cytotoxic reaction and further support the involvement of activated T lymphocytes in the early blisters of TEN.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4