IFN-gamma-Dependent Reduction of Erythrocyte Life Span Leads to Anemia during Mycobacterial Infection

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Gomes, AC (Author) Other; Moreira, AC (Author) Other; Silva, T (Author) Other; Neves, JV (Author) Other; Mesquita, G (Author) Other; Agostinho Almeida (Author) FFUP; Barreira Silva, P (Author) Other; Fernandes, R (Author) Other; Resende, M (Author) Other; Appelberg, R (Author) ICBAS; Rodrigues, P (Author) ICBAS; Gomes, MS (Author) ICBAS

Journal

Title: Journal of Immunology

Vol. 203

Pages: 2485-2496

ISSN: 0022-1767

Publisher: American Association of Immunologists

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 22 Citations

Other information

Authenticus ID: P-00R-3EQ

DOI: 10.4049/jimmunol.1900382

Abstract (EN): Anemia is a frequent and challenging complication of mycobacterial infections. We used a model of disseminated Mycobacterium avium infection in mice to investigate the mechanisms of mycobacteria-induced anemia. We found increased formation of RBC in the bone marrow and spleen of infected mice. Infection induced reticulocytosis and the premature egress of immature progenitors to the systemic circulation in an IFN-gamma (IFNG)-dependent way. The newly formed RBC had reduced CD47 surface expression and a reduced life span and were phagocytosed in the liver of infected mice, increasing iron recycling in this organ. The increased engulfment and degradation of RBC was independent of IFNG sensing by macrophages. Together, our findings demonstrate that mycobacterial infection alters the formation of erythrocytes, leading to their accelerated removal from circulation and hemolytic anemia. This comprehensive elucidation of the mechanisms underlying mycobacteria-induced anemia has important implications for its efficient clinical management.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12