HLA and Delayed Drug-Induced Hypersensitivity

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Sousa Pinto, B (Author) FMUP; Correia, C (Author) Other; Gomes, L (Author) Other; Gil Mata, S (Author) Other; Araujo, L (Author) FMUP; Correia, O (Author) FMUP; Delgado, L (Author) FMUP

Journal

Title: International Archives of Allergy and Immunology

Vol. 170

Pages: 163-179

ISSN: 1018-2438

Publisher: Karger

Indexing

ISI Web of Knowledge - 32 Citations

Scopus - 36 Citations

Other information

Authenticus ID: P-00M-4D8

DOI: 10.1159/000448217

Abstract (EN): Delayed drug allergy reactions (DDAR) are potentially fatal. Certain human leukocyte antigen (HLA) alleles have been associated with delayed allergy reactions following the administration of particular drugs. Examples are HLA-B*57:01 (abacavir), HLA-B*15:02/HLA-A*31:01 (carbamazepine), and HLA-B*58:01 (allopurinol). Based on the identification of these associations, it may now be possible to prevent certain allergy reactions that were, until recently, considered unpredictable. In this review, we will focus on the pharmacogenetics of the best-studied associations between specific HLA alleles and delayed allergy reactions and describe the pathogenesis models proposed so far. Finally, we will evaluate the genetic screening strategies available and discuss the clinical relevance of a better understanding of the immunogenetics and mechanisms involved in DDAR. (C) 2016 S. Karger AG, Basel

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 17