New insights on hormones and factors that modulate Sertoli cell metabolism

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Rato, L (Author) Other; Meneses, MJ (Author) Other; Silva, BM (Author) Other; sousa, m (Author) ICBAS; Alves, MG (Author) Other; Oliveira, PF (Author) ICBAS

Journal

Title: Histology and Histopathology

Vol. 31

Pages: 499-513

ISSN: 0213-3911

Publisher: Plaza Fuensanta

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 16 Citations

Other information

Authenticus ID: P-00K-94P

DOI: 10.14670/hh-11-717

Abstract (EN): Sertoli cells (SCs) play a key role in spermatogenesis by providing the physical support for developing germ cells and ensuring them the appropriate nutrients, energy sources, hormones, and growth factors. The control of SCs metabolism has been in the spotlight for reproductive biologists, since it may be crucial to determine germ cells' fate. Indeed, the maintenance of spermatogenesis is highly dependent on the metabolic cooperation established between SCs and germ cells, though this event has been overlooked. It depends on the orchestration of various metabolic pathways and an intricate network of signals. Several factors and/or hormones modulate the metabolic activity of SCs, which are major targets for the hormonal signalling that regulates spermatogenesis. Any alteration in the regulation of these cells' metabolic behaviour may compromise the normal development of spermatogenesis and consequently, male fertility. In this context, SC metabolism arises as a key regulation point for spermatogenesis. Herein, we present an up-to-date overview on the impact of hormones and factors that modulate SC metabolism, with special focus on glycolytic metabolism, highlighting their relevance in determining male reproductive potential.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15