BIOCHEMICAL AND GENETIC-STUDIES ON RABBIT HEMOGLOBIN .2. ELECTROPHORETIC POLYMORPHISM OF THE ALPHA-CHAIN

• Type: Article in International Scientific Journal
• Date: 1990

Authors

ferrand, n (Author) FCUP

Journal

Title: Biochemical Genetics

Vol. 28

Pages: 117-122

ISSN: 0006-2928

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-001-RVJ

DOI: 10.1007/bf00561331

Abstract (EN): A genetic polymorphism of rabbit (Oryctolagus cuniculus) hemoglobin ¿ chain is demonstrated by means of acid starch gel electrophoresis. The polymorphism is not detected by isoelectric focusing and may be based upon neutral for neutral amino acid substitutions in accordance with previous findings by means of amino acid sequencing. Segregation analysis was performed on 15 matings with 49 offspring and confirmed the initial genetic hypothesis of three common codominant alleles at an autosomal locus. The calculated gene frequencies in a random sample of 86 unrelated individuals are HBA*1 = 0.73, HBA*2 = 0.22, and HBA*3 = 0.05.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6