Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Carneiro, M (Author) Other; Rubin, CJ (Author) Other; Di Palma, F (Author) Other; Albert, FW (Author) Other; Alfoeldi, J (Author) Other; Barrio, AM (Author) Other; Pielberg, G (Author) Other; Rafati, N (Author) Other; Sayyab, S (Author) Other; Turner Maier, J (Author) Other; Younis, S (Author) Other; Afonso, S (Author) Other; Aken, B (Author) Other; Alves, JM (Author) Other; Barrell, D (Author) Other; Bolet, G (Author) Other; Boucher, S (Author) Other; Burbano, HA (Author) Other; Campos, R (Author) Other; Chang, JL (Author) Other; Duranthon, V (Author) Other; Fontanesi, L (Author) Other; Garreau, H (Author) Other; Heiman, D (Author) Other; Johnson, J (Author) Other; Mage, RG (Author) Other; Peng, Z (Author) Other; Queney, G (Author) Other; Rogel Gaillard, C (Author) Other; Ruffier, M (Author) Other; Searle, S (Author) Other; Villafuerte, R (Author) Other; Xiong, AQ (Author) Other; Young, S (Author) Other; Forsberg Nilsson, K (Author) Other; Good, JM (Author) Other; Lander, ES (Author) Other; ferrand, n (Author) FCUP; Lindblad Toh, K (Author) Other; Andersson, L (Author) Other

Journal

Title: Science

Vol. 345

Pages: 1074-1079

ISSN: 0036-8075

Publisher: American Association for the Advancement of Science

Indexing

ISI Web of Knowledge - 263 Citations

Scopus - 283 Citations

Other information

Authenticus ID: P-009-SDB

DOI: 10.1126/science.1253714

Abstract (EN): The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6