Initial sequence and comparative analysis of the cat genome

• Type: Another Publication in an International Scientific Journal
• Date: 2007

Authors

Pontius, JU (Author) Other; Mullikin, JC (Author) Other; Smith, DR (Author) Other; Lindblad Toh, K (Author) Other; Gnerre, S (Author) Other; Clamp, M (Author) Other; Chang, J (Author) Other; Stephens, R (Author) Other; Neelam, B (Author) Other; Volfovsky, N (Author) Other; Schaffer, AA (Author) Other; Agarwala, R (Author) Other; Narfstrom, K (Author) Other; Murphy, WJ (Author) Other; Giger, U (Author) Other; Roca, AL (Author) Other; Agostinho Antunes (Author) REIT; Menotti Raymond, M (Author) Other; Yuhki, N (Author) Other; Pecon Slattery, J (Author) Other; Johnson, WE (Author) Other; Bourque, G (Author) Other; Tesler, G (Author) Other; O'Brien, SJ (Author) Other; Brand, A (Author) Other; Ebling, H (Author) Other; Saranga, DJ (Author) Other; Rubenfield, M (Author) Other; Parisi, MJ (Author) Other; Tao, W (Author) Other; Tusneem, N (Author) Other; David, R (Author) Other; Gustafson, E (Author) Other; Tsolas, J (Author) Other; McKernan, K (Author) Other

Journal

Title: Genome Research

Vol. 17

Pages: 1675-1689

ISSN: 1088-9051

Publisher: Cold Spring Harbor Laboratory Press

Indexing

ISI Web of Knowledge - 254 Citations

Scopus - 279 Citations

Other information

Authenticus ID: P-004-6GP

DOI: 10.1101/gr.6380007

Abstract (EN): The genome sequence (1.9-fold coverage) of an inbred Abyssinian domestic cat was assembled, mapped, and annotated with a comparative approach that involved cross-reference to annotated genome assemblies of six mammals (human, chimpanzee, mouse, rat, dog, and cow). The results resolved chromosomal positions for 663,480 contigs, 20,285 putative feline gene orthologs, and 133,499 conserved sequence blocks (CSBs). Additional annotated features include repetitive elements, endogenous retroviral sequences, nuclear mitochondrial (numt) sequences, micro-RNAs, and evolutionary breakpoints that suggest historic balancing of translocation and inversion incidences in distinct mammalian lineages. Large numbers of single nucleotide polymorphisms (SNPs), deletion insertion polymorphisms (DIPs), and short tandem repeats (STRs), suitable for linkage or association studies were characterized in the context of long stretches of chromosome homozygosity. In spite of the light coverage capturing -65% of euchromatin sequence from the cat genome, these comparative insights shed new light on the tempo and mode of gene/genome evolution in mammals, promise several research applications for the cat, and also illustrate that a comparative approach using more deeply covered mammals provides an informative, preliminary annotation of a light (1.9-fold) coverage mammal genome sequence.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15