Vancomycin-loaded chitosan aerogel particles for chronic wound applications

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Clara López-Iglesias (Author) Other; Joana Barros (Author) Other; Inés Ardao (Author) Other; Fernando M. Monteiro (Author) FEUP; Carmen Alvarez-Lorenzo (Author) Other; José L. Gómez-Amoza (Author) Other; Carlos A. García-González (Author) Other

Journal

Title: Carbohydrate Polymers

Vol. 204

Pages: 223-231

ISSN: 0144-8617

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 58 Citations

Other information

Authenticus ID: P-00P-RB6

DOI: 10.1016/j.carbpol.2018.10.012

Abstract (EN): Chronic wounds are a prevailing cause of decreased quality of life, being microbial burden a factor hindering the normal wound healing process. Aerogels are nanostructured materials with large surface area (> 250m(2)/g) and high porosity (> 96%). In this work, vancomycin-loaded chitosan aerogel beads were tested as a potential formulation to treat and prevent infections at the wound site. Processing of chitosan in the form of aerogels endowed this polysaccharide with enhanced water sorption capacity and air permeability. The morphological and textural properties of the particles were studied by image and N-2 adsorption-desorption analysis and scanning electron microscopy. Vancomycin content and release profiles from aerogel carriers showed a fast drug release that permitted to efficiently achieve local therapeutic levels. Cell studies with fibroblasts and antimicrobial tests against S. aureus showed that the vancomycin-loaded aerogel particles were cytocompatible and effective in preventing high bacterial loads at the wound site.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9