Electrochemical Behavior of a Mitochondria-Targeted Antioxidant at an Interface between Two Immiscible Electrolyte Solutions: An Alternative Approach to Study Lipophilicity

• Type: Article in International Scientific Journal
• Date: 2018

Authors

José A. Ribeiro (Author) FCUP; Benfeito, S (Author) Other; Fernando Cagide (Author) FCUP; Teixeira, J (Author) Other; Oliveira, PJ (Author) Other; Fernanda Borges (Author) FCUP; Silva, F (Author) FCUP; Carlos M Pereira (Author) FCUP

Journal

Title: Analytical Chemistry

Vol. 90

Pages: 7989-7996

ISSN: 0003-2700

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-00P-096

DOI: 10.1021/acs.analchem.8b00787

Abstract (EN): In this work, we report for the first time the accumulation activity by energized rat heart mitochondria and the ionic transfer process at a liquid liquid interface of a novel mitochondria-targeted antioxidant, named as AntiOxCIN(4), which is structurally based on a hydroxycinnamic acid. Lipophilicity studies conducted at the water/1,6-dichlorohexane (DCH) interface allowed the building up of an ionic partition diagram of AntiOxCIN(4) in accordance with the electrochemical data obtained. The partition coefficients of both positively charged (-2.3) and zwitterionic (0.2) forms of the antioxidant were determined. This study contributed to gaining an insight about the ability of the synthesized antioxidants to cross biomembrane barriers by using an interface between two immiscible electrolyte solutions (ITIES) as a model system.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8