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Profiling of Heterobranchia Sea Slugs from Portuguese Coastal Waters as Producers of Anti-Cancer and Anti-Inflammatory Agents

Title
Profiling of Heterobranchia Sea Slugs from Portuguese Coastal Waters as Producers of Anti-Cancer and Anti-Inflammatory Agents
Type
Article in International Scientific Journal
Year
2018-04-27
Authors
Fátima Fernandes
(Author)
FFUP
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Áurea Madureira-Carvalho
(Author)
FFUP
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Alexandre Lobo-da-Cunha
(Author)
ICBAS
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Gonçalo Calado
(Author)
Other
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Journal
Title: MoleculesImported from Authenticus Search for Journal Publications
Serial No. 9 Vol. 23 No. 2288
Final page: 1027
ISSN: 1420-3049
Publisher: MDPI
Other information
Authenticus ID: P-00P-0R2
Abstract (EN): Bioprospection of marine invertebrates has been predominantly biased by the biological richness of tropical regions, thus neglecting macro-organisms from temperate ecosystems. Species that were not the object of studies on their biochemical composition include the Heterobranchia gastropods Armina maculata, Armina tigrina and Aglaja tricolorata, inhabitants of the Portuguese Atlantic coastal waters. Here, we present for the first time the fatty acid profile of neutral lipids and homarine content of these three species. Qualitative and quantitative differences in the fatty acid content among species points to the existence of a fatty acid profile of neutral lipids, particularly of each genus. The results from cytotoxicity assays, using the acetonic extracts of the gastropods on human gastric adenocarcinoma (AGS) and human lung adenocarcinoma (A549) cell lines, revealed a pronounced cytotoxic effect of the A. tigrina extract on both cell lines (IC50 values of 68.75 and 69.77 g mL(-1) for AGS and A549, respectively). It is worth noting the significant reduction of NO levels in LPS-challenged RAW 264.7 macrophages exposed to A. tricolorata extract, at concentrations as low as 125 g mL(-1).
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 15
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