Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Teixeira, J (Author) Other; Oliveira, C (Author) Other; Amorim, R (Author) Other; Fernando Cagide (Author) FCUP; Garrido, J (Author) Other; José A. Ribeiro (Author) FCUP; Carlos M Pereira (Author) FCUP; Silva, F (Author) FCUP; Paula B Andrade (Author) FFUP; Oliveira, PJ (Author) Other; Fernanda Borges (Author) FCUP

Journal

Title: Scientific Reports

Vol. 7

ISSN: 2045-2322

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 35 Citations

Other information

Authenticus ID: P-00N-MQA

DOI: 10.1038/s41598-017-07272-y

Abstract (EN): Oxidative stress and mitochondrial dysfunction have been associated with metabolic and agerelated diseases. Thus, the prevention of mitochondrial oxidative damage is nowadays a recognized pharmacological strategy to delay disease progression. Epidemiological studies suggested an association between the consumption of polyphenol-rich diet and the prevention of different pathologies, including diseases with a mitochondrial etiology. The development of mitochondrialtargeted antioxidants based on dietary antioxidants may decrease mitochondrial oxidative damage. Herein, we report the design and synthesis of two new mitochondriotropic antioxidants based on hydroxybenzoic acids (AntiOxBENs). The results obtained showed that the novel antioxidants are accumulated inside rat liver mitochondria driven by the organelle transmembrane electric potential and prevented lipid peroxidation, exhibiting low toxicity. Some of the observed effects on mitochondrial bioenergetics resulted from an increase of proton leakage through the mitochondrial inner membrane. The new derivatives present a higher lipophilicity than the parent compounds (protocatechuic and gallic acids) and similar antioxidant and iron chelating properties. AntiOxBENs are valid mitochondriotropic antioxidant prototypes, which can be optimized and used in a next future as drug candidates to prevent or slow mitochondrial oxidative stress associated to several pathologies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18