Current Neurogenic and Neuroprotective Strategies to Prevent and Treat Neurodegenerative and Neuropsychiatric Disorders

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Carvalho, IM (Author) Other; Coelho, PB (Author) Other; Paulo Costa (Author) FFUP; Marques, CS (Author) Other; Oliveira, RS (Author) Other; Ferreira, DC (Author) FFUP

Journal

Title: NeuroMolecular Medicine

Vol. 17

Pages: 404-422

ISSN: 1535-1084

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 8 Citations

Other information

Authenticus ID: P-00G-MCY

DOI: 10.1007/s12017-015-8369-3

Abstract (EN): The adult central nervous system is commonly known to have a very limited regenerative capacity. The presence of functional stem cells in the brain can therefore be seen as a paradox, since in other organs these are known to counterbalance cell loss derived from pathological conditions. This fact has therefore raised the possibility to stimulate neural stem cell differentiation and proliferation or survival by either stem cell replacement therapy or direct administration of neurotrophic factors or other proneurogenic molecules, which in turn has also originated regenerative medicine for the treatment of otherwise incurable neurodegenerative and neuropsychiatric disorders that take a huge toll on society. This may be facilitated by the fact that many of these disorders converge on similar pathophysiological pathways: excitotoxicity, oxidative stress, neuroinflammation, mitochondrial failure, excessive intracellular calcium and apoptosis. This review will therefore focus on the most promising achievements in promoting neuroprotection and neuroregeneration reported to date.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19