A Novel Small-Caliber Bacterial Cellulose Vascular Prosthesis: Production, Characterization, and Preliminary in Vivo Testing

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Leitão, AF (Author) Other; Miguel Faria (Author) ICBAS; Faustino, AMR (Author) Other; Moreira, R (Author) Other; Mela, P (Author) Other; Loureiro, L (Author) Other; Silva, I (Author) Other; Gama, M (Author) Other

Journal

Title: Macromolecular Bioscience

Vol. 16

Pages: 139-150

ISSN: 1616-5187

Publisher: Wiley-Blackwell

Indexing

Scopus - 1 Citation

Other information

Authenticus ID: P-00K-3RV

DOI: 10.1002/mabi.201500251

Abstract (EN): Vascular grafts are used to bypass damaged or diseased blood vessels. Bacterial cellulose (BC) has been studied for use as an off-the-shelf graft. Herein, we present a novel, cost-effective, method for the production of small caliber BC grafts with minimal processing or requirements. The morphology of the graft wall produced a tensile strength above that of native vessels, performing similarly to the current commercial alternatives. As a result of the production method, the luminal surface of the graft presents similar topography to that of native vessels. We have also studied the in vivo behavior of these BC graft in order to further demonstrate their viability. In these preliminary studies, 1 month patency was achieved, with the presence of neo-vessels and endothelial cells on the luminal surface of the graft. Bacterial cellulose (BC) is analyzed for use as an off-the-shelf vascular graft. The authors present a novel, facile, and cost-effective method for small caliber BC grafts production. The morphology of the graft wall, tensile strength, and luminal topography all show promising results. The in vivo behavior of these BC grafts further demonstrate their viability achieving, one month patency with neo-vessels, and endothelial cells presenting on the luminal surface of the graft. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Language: English

Type (Professor's evaluation): Scientific