EFFECTS OF NEBIVOLOL STEREOISOMERS ON THE ACTION OF ADRENALINE ON BLOOD-PRESSURE, HEART-RATE AND BLOOD-LEVELS OF NORADRENALINE AND DOPEG

• Type: Article in International Scientific Journal
• Date: 1992

Authors

Borges, Nuno (Author) Other; Martel, F (Author) Other; BRANCO, D (Author) Other; OSSWALD, W (Author) Other

Journal

Title: Journal of Autonomic Pharmacology

Vol. 12

Pages: 429-435

ISSN: 0144-1795

Publisher: Blackwell

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-001-NZB

DOI: 10.1111/j.1474-8673.1992.tb00391.x

Abstract (EN): 1 Nebivolol (a new beta1-adrenoceptor blocking drug) has particular effects on the cardiovascular system, i.e. it induces hypotension without affecting cardiac function or increasing peripheral vascular resistances. In this study, we aimed to evaluate the effects of nebivolol and its stereoisomers on the actions of adrenaline (AD) at the cardiovascular level as well as at the prejunctional level (as ascertained by modification of noradrenaline (NA) and dihydroxyphenylglycol (DOPEG) plasma levels in the anaesthetized dog. 2 AD infusion(0.1 mug kg-1 min-1) did not induce statistically significant changes in mean blood pressure and heart rate; it caused a pronounced and sustained rise of AD levels, no significant alterations in NA levels and a marked, progressive and sustained increase in DOPEG levels. 3 Mean blood pressure was not affected by any of the nebivolol isomers. d- and dl-nebivolol in the two doses used (0.3 and 0.03 mg kg-1 in 15 min) caused a significant and dose-dependent decrease in heart rate. Plasma levels of AD and NA were not changed by any of the nebivolol isomers tested. However, all of them significantly reduced the increase in plasma levels of DOPEG induced by adrenaline infusion. 4 We conclude (1) that AD infusion in the dog facilitates NA release and that DOPEG is a good index of this effect; and (2) nebivolol appears to act at the prejunctional level, reducing the increase in NA release induced by adrenaline, as shown by the effect on DOPEG plasma levels.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7