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Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry

Title
Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry
Type
Article in International Scientific Journal
Year
2015
Authors
Fernando Cagide
(Author)
FCUP
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Silva, T
(Author)
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Reis, J
(Author)
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Gaspar, A
(Author)
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Fernanda Borges
(Author)
FCUP
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Gomes, LR
(Author)
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Low, JN
(Author)
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Journal
Vol. 51
Pages: 2832-2835
ISSN: 1359-7345
Other information
Authenticus ID: P-00A-5XM
Abstract (EN): The discovery of potent and selective monoamine oxidase-B inhibitors for the management of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is still a challenging endeavor. Herein, we report the discovery of two new classes of potent and selective MAO-B inhibitors based on chromane-2,4-dione and chromone-3-carboxamide scaffolds.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 4
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