Potentiometric determination of chloride in parenteral and haemodialysis solutions by FIA

• Type: Article in International Scientific Journal
• Date: 1997

Authors

Lapa, RAS (Author) FFUP; Lima, JLFC (Author) FFUP; Barrado, E (Author) Other; Vela, H (Author) Other

Journal

Title: Farmaco

Vol. 52

Pages: 127-130

ISSN: 0014-827X

Publisher: Elsevier B.V.

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-001-C0S

Abstract (EN): This work describes the development and use of two flow-Injection analysis manifolds with potentiometric detection, to perform chloride determinations in parenteral and haemodialysis solutions. The FIA manifold used in the determination of chloride in parenteral solutions was similar to the utilized in haemodialysis solutions. In the latest it was used a dialysis unit intended to enable the adjustment of the chloride concentration level within the linear response range of the tubular chloride sensitive electrode based on a homogeneous crystalline membrane. Both manifolds were optimized in order to enable sample analysis within the concentration range of chloride anion present in these pharmaceutical formulations, without any sample pre-treatment. The chloride determination in samples of parenteral and haemodialysis solutions was performed using the manifolds shown in this work and using conventional methodology. The comparative evaluation of the results given by both methodologies showed that there was a good agreement between them, but the FIA methodology presents some advantages regarding automatisation, performing time and the fact that it does not require any sample pre-treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4