Polyphenolic characterisation and bioactivity of an Oxalis pes-caprae L. leaf extract

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Marisa C. Gaspar (Author) Other; Diogo A. Fonseca (Author) Other; Manuel J. Antunes (Author) Other; Christian Frigerio (Author) Other; Nelson G. M. Gomes (Author) Other; M. Vieira (Author) Other; Armanda E. Santos (Author) Other; Maria T. Cruz (Author) Other; Maria D. Cotrim (Author) Other; Maria G. Campos (Author) Other

Journal

Title: Natural Product Research

Vol. 32

Pages: 732-738

ISSN: 1478-6419

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 2 Citations

Other information

Authenticus ID: P-00N-RGR

DOI: 10.1080/14786419.2017.1335728

Abstract (EN): The present work is focused on the characterisation of the polyphenolic content of an Oxalis pes-caprae L. leaf extract and on the evaluation of its bioactivity with particular interest on its vascular activity and antioxidant potential. The polyphenolic content was characterised by HPLC-DAD and LC-MS/MS. The vascular activity was evaluated according to the influence on the serotonergic and adrenergic systems of the human internal mammary artery (HIMA). Antioxidant and neuroprotective studies were also conducted. Several luteolin and apigenin derivatives were identified as main constituents of the extract, which did not present any contractile effect nor had any effect on the serotonergic system of HIMA. However, it showed antagonistic effect on the adrenergic system, inhibiting the contraction to noradrenaline (reduction of 58.44% of maximum contraction). The extract showed antioxidant activity and standardised luteolin and apigenin derivatives showed neuroprotective potential, particularly homoorientin. [GRAPHICS] .

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7