Computational modeling of radiobiological effects in bone metastases for different radionuclides

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Francisco D. C. Guerra Liberal (Author) FEUP; Adriana Alexandre S. Tavares (Author) Other; João Manuel R. S. Tavares (Author) FEUP

Journal

Title: International Journal of Radiation Biology

Vol. 93 No. 6

Pages: 627-636

ISSN: 0955-3002

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 1 Citation

ISI Web of Science

Scopus - 2 Citations

Scientific classification

CORDIS: Technological sciences

FOS: Medical and Health sciences

Other information

Authenticus ID: P-00R-B3S

DOI: 10.1080/09553002.2017.1294274

Abstract (EN): : Computational simulation is a simple and practical way to study and to compare a variety of radioisotopes for different medical applications, including the palliative treatment of bone metastases. This study aimed to evaluate and compare cellular effects modelled for different radioisotopes currently in use or under research for treatment of bone metastases using computational methods. Methods: Computational models were used to estimate the radiation-induced cellular effects (Virtual Cell Radiobiology algorithm) post-irradiation with selected particles emitted by Strontium-89 (89Sr), Samarium-153 (153Sm), Lutetium-177 (177Lu), and Radium-223 (223Ra). Results: Cellular kinetics post-irradiation using 89Sr β- particles, 153 Sm β− particles, 177Lu β− particles and 223Ra α particles showed that the cell response was dose- and radio- nuclide-dependent. 177Lu beta minus particles and, in particular, 223Ra alpha particles, yielded the lowest survival fraction of all investigated particles. Conclusions: 223Ra alpha particles induced the highest cell death of all investigated particles on metastatic prostate cells in comparison to irradiation with β− radionuclides, two of the most frequently used radionuclides in the palliative treatment of bone metastases in clinical routine practice. Moreover, the data obtained suggest that the used computational methods might provide some perception about cellular effects following irradiation with different radionuclides.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10