Anti-inflammatory properties of the stem bark from the herbal drug Vitex peduncularis Wall. ex Schauer and characterization of its polyphenolic profile

• Type: Article in International Scientific Journal
• Date: 2017-05-11

Authors

Federico Ferreres (Author) Other; Sutsawat Duangsrisai (Author) Other; Nelson G.M. Gomes (Author) FFUP; Rungcharn Suksungworn (Author) Other; David M. Pereira (Author) FFUP; Angel Gil-Izquierdo (Author) Other; Patricia Valentão (Author) FFUP; Kiattawee Choowongkomon (Author) Other; Paula B. Andrade (Author) FFUP

Journal

Title: Food and Chemical Toxicology

Vol. 106

Pages: 8-16

ISSN: 0278-6915

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 10 Citations

Other information

Authenticus ID: P-00M-TJQ

DOI: 10.1016/j.fct.2017.05.020

Abstract (EN): Vitex spp. have been reported as constituents of herbal preparations, namely Vitex peduncularis, commonly used in Asian countries. Unlike other species extensively investigated, reports on the biological activities and chemical profile of V. peduncularis are still scarce. In this work, the polyphenolic profile of V. peduncularis stem bark was unveiled, revealing a high content of apigenin and luteolin derivatives. More than 20 polyphenols were identified and quantitated for the first time, including C-rhamnosyl flavones infrequently reported. Regarding potential anti-inflammatory properties, the methanolic extract of the stem bark significantly reduced the levels of NO in macrophages, which may be a consequence of scavenging effect upon (NO)-N-center dot. Significant inhibition of phospholipase A(2) activity was also noted. Consequently, the therapeutic applicability of this edible plant is also broadened due to the anti-inflammatory properties found.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9