Urinary bladder chemical carcinogenesis in laboratory rodents as an experimental model [Carcinogénesis química de vejiga urinaria en roedores de laboratorio como modelo experimental]

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Antonieta Alvarado (Author) Other; Regina Arantes Rodrigues (Author) Other; Carmen Vasconcelos Nóbrega (Author) Other; Rui Gil da Costa (Author) FEUP; Maria do Rosário Pinto Leite (Author) Other; Ana Isabel Faustino Rocha (Author) Other; Paula Alexandra Oliveira (Author) Other

Journal

Title: Revista Venezolana de Oncologia

Vol. 27 No. 1

Pages: 57-63

ISSN: 0798-0582

Publisher: Sociedad Venezolana de Oncologia

Indexing

Scopus - 0 Citations

Associated Projects

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

Other information

Authenticus ID: P-00A-7AK

Abstract (EN): Urotelial cancer, is a common malignancy in the worldwide, is an important contributor to the overall international cancer burden. The urotelial tumors induced by chemical carcinogens in the laboratory animals repeat many of the features observed in the human urotelial neoplasia. The urotelial tumors chemically induced in the urinary bladder are morphologically and histologically similar to the human urotelial tumors. Like human urotelial carcinogenesis, rodent carcinogenesis is a multistep process that involves sequential progression from simple hyperplasia to invasive carcinoma or papillary tumors through varying lesions. In addition, the rodent tumors (Rattus norvegicus) and (Mus musculus) express several biochemical and molecular markers that are also expressed in the human urotelial tumors. For this reason, the rodent urinary bladder carcinogenesis is a good animal system to evaluate chemo preventive agents and to study cancer pathways.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7