Spray drying as a viable process to produce nano-hydroxyapatite/chitosan (n-HAp/CS) hybrid microparticles mimicking bone composition

• Type: Article in International Scientific Journal
• Date: 2016

Authors

G. Ruphuy (Author) FEUP; A. Saralegi (Author) Other; J. C. Lopes (Author) FEUP; M. M. Dias (Author) FEUP; M. F. Barreiro (Author) Other

Journal

Title: Advanced Powder Technology

Vol. 27 No. 2

Pages: 575-583

ISSN: 0921-8831

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 30 Citations

INSPEC

Scientific classification

CORDIS: Technological sciences > Engineering > Chemical engineering ; Technological sciences > Technology > Materials technology

FOS: Engineering and technology > Chemical engineering

Associated Projects

LSRE-LCM - Laboratório de Processos de Separação e Reação - Laboratório de Catálise e Materiais

LSRE/LCM LA - RL2_P2 - Mixing in Chemical Reactors

Other information

Authenticus ID: P-00K-DDN

DOI: 10.1016/j.apt.2016.02.010

Abstract (EN): In this work nano-hydroxyapatite/chitosan (n-HAp/CS) hybrid microparticles were prepared by spray drying following a methodology where, in a first step, aqueous nanodispersions of n-HAp in the presence of chitosan were produced by fast stirring at pH values below and above chitosan pKa (5.5 and 7.0, respectively). The mixing system used allowed the production of homogeneous and stable nanodispersions, and the subsequent spray-dried microparticles, incorporating highly pure HAp nanoparticles of approximately 50 nm, were successfully produced without degrading the organic component, chitosan. Comparatively with the n-HAp/CS-7.0, the n-HAp/CS-5.5 dispersions were characterized by a lower particle size and a higher zeta potential, being then more stable. Differences in the spray-dried microparticles were also evident from a morphological point of view. HApCS-5.5 microparticles, which present an average size in volume of 15.8 mu m and n-HAp crystals homogenously distributed, were found to be preferred over the HApCS-7.0 counterparts, which require an extra step in the productive process and presented a tendency to form large agglomerates. Both prepared hybrid particles presented similar composition to that one of natural bone (HAp/CS of 70/30) and no traces of KCl salts were observed if a washed n-HAp paste was used.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9