Expression of Estrogen Receptors Alpha (ER-alpha), Beta (ER-beta), and G Protein-Coupled Receptor 30 (GP-alpha) in Testicular Tissue of Men with Klinefelter Syndrome

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Bernardino, RL (Author) Other; Alves, MG (Author) Other; Silva, J (Author) Other; barros, a (Author) FMUP; Ferraz, L (Author) Other; sousa, m (Author) ICBAS; Sa, R (Author) Other; Oliveira, PF (Author) ICBAS

Journal

Title: Hormone and Metabolic Research

Vol. 48

Pages: 413-415

ISSN: 0018-5043

Publisher: Thieme

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-00M-BG2

DOI: 10.1055/s-0042-105151

Abstract (EN): Men with Klinefelter syndrome (KS) present severe hormonal dysregulation, particularly elevated serum estradiol concentration. Estrogens act through specific receptors and regulate testes development and spermatogenesis. Herein, we evaluated GPR30, ERa, and ERP mRNA expression in testis of KS men and men with 46XY karyotype by reverse transcriptase and quantitative PCR. ERP transcripts are the most abundant in testicular tissue of 46XY men. Notably, testicular GPR30 transcription in KS men was approximately 12 times higher. Since GPR30 is essential to mediate estrogen effects over steroidogenesis, our data illustrate that GPR30 may underpin the testicular alterations observed in KS men.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3