Higher C-Reactive Protein Predicts Worse Prognosis in Acute Heart Failure Only in Noninfected Patients

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Lourenco, P (Author) FMUP; Araújo JP (Author) FMUP; Paulo, C (Author) Other; Mascarenhas, J (Author) Other; Friões F (Author) FMUP; Azevedo A (Author) FMUP; Bettencourt P (Author) FMUP

Journal

Title: Clinical Cardiology

Vol. 33

Pages: 708-714

ISSN: 0160-9289

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 19 Citations

Scopus - 24 Citations

Other information

Authenticus ID: P-003-195

DOI: 10.1002/clc.20812

Abstract (EN): Background: The prognostic role of C-reactive protein (CRP) in acute heart failure (HF) is not fully understood, and the impact of an infectious process in its risk-stratification power was not previously evaluated. Hypothesis: As CRP is an inflammatory marker, its prognostic value in acute HF is probably different in patients with and without concurrent infection. Methods: We recruited patients admitted to our hospital due to acute HF from October 2006 to October 2007. All patients were given treatment at the discretion of the attending physician. Serum CRP was measured at discharge in 225 patients. We followed patients for 3 months after discharge to assess occurrence of all-cause death or readmission due to HF. Infection was defined according to diagnoses registered on the discharge record. Patients were classified according to CRP tertiles, in the entire sample and in groups according to infection occurrence. Results: An infectious condition occurred in 109 patients (first and second CRP tertiles: 8.8 and 27.4 mg/L, respectively). No infection was detected in 116 patients (5.0 and 12.3 mg/L, respectively). In the group with infection, CRP was not a good predictor of adverse outcome. In the noninfected group, the hazard ratio of those with CRP >12.3 mg/L was 2.46 (95% confidence interval: 1.29-4.70) in comparison with those with lower CRP. Adjusted hazard ratio for ischemic heart disease and diabetes was 2.03 (95% confidence interval: 1.06-3.91). Conclusions: CRP had no prognostic value in acute HF patients with an infectious complication. Noninfected patients with higher CRP at discharge had worse prognosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7