KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program

• Type: Another Publication in an International Scientific Journal
• Date: 2008

Authors

van Krieken, JHJM (Author) Other; Jung, A (Author) Other; Kirchner, T (Author) Other; Carneiro F (Author) FMUP; Seruca, R (Author) FMUP; Bosman, FT (Author) Other; Quirke, P (Author) Other; Flejou, JF (Author) Other; Hansen, TP (Author) Other; de Hertogh, G (Author) Other; Jares, P (Author) Other; Langner, C (Author) Other; Hoefler, G (Author) Other; Ligtenberg, M (Author) Other; Tiniakos, D (Author) Other; Tejpar, S (Author) Other; Bevilacqua, G (Author) Other; Ensari, A (Author) Other

Journal

Title: Virchows Archiv

Vol. 453 No. 5

Pages: 417-431

ISSN: 0945-6317

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 241 Citations

Scopus - 263 Citations

Other information

Authenticus ID: P-003-VDP

DOI: 10.1007/s00428-008-0665-y

Abstract (EN): Novel therapeutic agents targeting the epidermal growth factor receptor (EGFR) have improved outcomes for patients with colorectal carcinoma. However, these therapies are effective only in a subset of patients. Activating mutations in the KRAS gene are found in 30-40% of colorectal tumors and are associated with poor response to anti-EGFR therapies. Thus, KRAS mutation status can predict which patient may or may not benefit from anti-EGFR therapy. Although many diagnostic tools have been developed for KRAS mutation analysis, validated methods and standardized testing procedures are lacking. This poses a challenge for the optimal use of anti-EGFR therapies in the management of colorectal carcinoma. Here we review the molecular basis of EGFR-targeted therapies and the resistance to treatment conferred by KRAS mutations. We also present guideline recommendations and a proposal for a European quality assurance program to help ensure accuracy and proficiency in KRAS mutation testing across the European Union.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15