Salt sensitivity of blood pressure in patients with psoriasis on ciclosporin therapy

• Type: Article in International Scientific Journal
• Date: 2005

Authors

magina, s (Author) FMUP; Santos, J (Author) Other; Coroas, A (Author) Other; José Oliveira (Author) FMUP; Maria Paula Serrão (Author) FMUP; soares-da-silva, p (Author) FMUP; Resende, C (Author) Other; Pestana M (Author) FMUP

Journal

Title: British Journal of Dermatology

Vol. 152 No. 4

Pages: 773-776

ISSN: 0007-0963

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 5 Citations

Other information

Authenticus ID: P-000-3XX

DOI: 10.1111/j.1365-2133.2005.06518.x

Abstract (EN): Background Hypertension is one of the main side-effects of long-term therapy with ciclosporin. However, the influence of salt intake on the 24-h mean blood pressure of patients with psoriasis treated with ciclosporin is not known. Objectives To evaluate, in patients with psoriasis, the sodium sensitivity of the ciclosporin-induced rise in blood pressure. Methods The 24-h ambulatory blood pressure was evaluated in 13 patients with psoriasis (age range 20-57 years) in two phases, before (phase I) and after the completion of 4 months of therapy with ciclosporin 3 mg kg(-1) daily (phase II). In both phases, the patients were studied in conditions of low sodium (LS) intake followed by a high sodium (HS) diet. Results Twenty-four-hour mean +/- SD blood pressure during LS and HS intake was, respectively, 86.3 +/- 1.6 mmHg and 85.5 +/- 1.8 mmHg during phase I, and 88.5 +/- 1.5 mmHg and 91.8 +/- 2.2 mmHg (P < 0.001 vs. phase I, HS; P < 0.05 vs. phase II, LS) during phase II. The median (interquartile range) sodium sensitivity index was greater during phase II than during phase I: - 0.0028 (- 0.0071 to 0.0009) vs. 0.0065 (- 0.0055 to 0.0258) (P < 0.02). The plasma levels and the daily urinary excretion of noradrenaline did not differ between phases I and II. Conclusions The ciclosporin-induced rise in blood pressure is sodium sensitive. It is also suggested that sympathetic activation is not involved in the pathogenesis of ciclosporin-induced rise in blood pressure.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4