Plasma alkaline phosphatase and survival in diabetic patients with acute myocardial infarction

• Type: Article in International Scientific Journal
• Date: 2016-06-01

Authors

José Pedro Nunes (Author) FMUP; Filipa Melão (Author) Other; Ana Rita Godinho (Author) Other; Joana D. Rodrigues (Author) Other; Maciel MJ (Author) FMUP

Journal

Title: Annals of Translational Medicine

Vol. 4 No. 210

Pages: 210-210

ISSN: 2305-5839

Publisher: AME Publishing Company

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00K-P6Y

DOI: 10.21037/atm.2016.06.01

Abstract (EN): Background: Alkaline phosphatase (ALP) removes phosphate groups from many types of molecules. The aim of the present research was to study the relation between plasma ALP and survival in diabetic patients with myocardial infarction. Methods: Retrospective study: from 954 admissions (15 months period) in a coronary care unit, we selected 200 admissions corresponding to 195 patients with myocardial infarction and diabetes mellitus. Survival after no less than 48 months, and up to 61 months, after the myocardial infarction episode, was under study, in association with ALP levels. Results: A relatively weak but significant correlation was seen between the peak plasma cardiac troponin I and ALP levels (r: 0.21, significance level: 0.003). Using the median value for ALP as cut-off (74 IU/L), plasma creatinine was significantly higher in patients with higher values for ALP. Patients with elevated ALP had decreased survival in Kaplan-Meier analysis (significance level in log-rank test: 0.032). This finding was noted for male patients (significance level in log-rank test: 0.035), but not for female patients (significance level in log-rank test: 0.497). Conclusions: Elevated ALP acts as a prognostic indicator of decreased survival in diabetic patients with acute myocardial infarction, possibly in association to decreased renal function. This finding is limited to male patients, pointing to a possible different role for phosphatase activity in cardiovascular disease in male and female diabetic patients.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5