The physiology of left ventricular pressure fall.

• Type: Article in International Scientific Journal
• Date: 2000

Authors

Leite-Moreira AF (Author) FMUP; Gillebert, TC (Author) Other

Journal

Title: Revista Portuguesa de Cardiologia

Vol. 19 No. 3

Pages: 1015-1021

ISSN: 0870-2551

Publisher: Sociedade Portuguesa De Cardiologia

Indexing

Scopus - 8 Citations

Other information

Authenticus ID: P-008-PVA

Abstract (EN): Left ventricular pressure (LVP) fall is the hemodynamic manifestation of myocardial relaxation. This paper reviews the most important aspects of LVP fall and its regulation by load, inactivation and nonuniformity. This regulation is explained in terms of calcium transients and cross-bridge mechanics. Specific effects of systolic pressure on LVP fall and their relation to systolic cardiac function are emphasized. These data constitute a conceptual framework for the analysis of myocardial relaxation in cardiovascular research and in the cardiac patient. Comparison of clinical and experimental data during manipulation of afterload should lead to an improved understanding of relaxation disturbances and to a therapeutic approach which is relevant from the pathophysiological point of view. LVP fall may provide useful and quantitative information on systolic LV function if measurements are performed under different conditions of systolic load.

Language: English

Type (Professor's evaluation): Scientific