Hypertension due to chronic blockade of P-I-purinoceptors

• Type: Article in International Scientific Journal
• Date: 1996

Authors

Guimaraes, S (Author) Other; Albino Teixeira, A (Author) FMUP

Journal

Title: Journal of Autonomic Pharmacology

Vol. 16

Pages: 367-370

ISSN: 0144-1795

Publisher: Blackwell

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 16 Citations

Other information

Authenticus ID: P-001-DA5

DOI: 10.1111/j.1474-8673.1996.tb00055.x

Abstract (EN): I Long-term treatment of rats with 1,3-dipropyl-8-sulphophenylxanthine (DPSPX), a nonselective antagonist of adenosine receptors, causes a hypertensive state. 2 In DPSPX-hypertensive rats, prejunctional alpha(2)-adrenoceptors become supersensitive to the selective alpha(2)-adrenoceptor agonist UK-14,304, while postjunctional adrenoceptor-mediated responses are not changed; furthermore, prejunctional beta-adrenoceptor-mediated facilitation of noradrenaline release is also enhanced. 3 In DPSPX-hypertensive rats, there are important morphological alterations of the small arteries, their lumina appearing strongly reduced and occasionally occluded by proliferation of the intimal cells. 4 In DPSPX-hypertensive rats, there is an increase in plasma renin, and captopril prevents not only the development of the hypertension but also the morphological changes in the arteries. 5 Other important changes occur in DPSPX-hypertensive rats: an alteration of the adrenergic regulation of the cardiac functions and an enhancement of perivascular neurotransmission. 6 These results suggest that adenosine may play an important role in the development of some kinds of human hypertension.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4