Abstract (EN):
Pulmonary arterial hypertension is a progressive syndrome based on diverse aetiologies, which is characterized by a persistent increase in pulmonary vascular resistance and overload of the right ventricle, leading to heart failure and death. Currently, none of the available treatments is able to cure pulmonary arterial hypertension; additional research is therefore needed to unravel the associated pathophysiological mechanisms. This review summarizes current knowledge related to this disorder, and the several experimental animal models that can mimic pulmonary arterial hypertension and are available for translational research. © 2016 Elsevier Masson SAS
Language:
English
Type (Professor's evaluation):
Scientific
Contact:
carmensb@med.up.pt
Notes:
<a href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord&KeyUT=000389290800007">Indexado na ISI Web of Science</a>
<a href="https://www.ncbi.nlm.nih.gov/pubmed/27595464">Indexado na Pubmed</a>
<a href="http://www.scopus.com/record/display.url?eid=2-s2.0-84994165256&origin=inward">Indexado na Scopus</a>