GABA DECREASES IN THE SPINAL-CORD DORSAL HORN AFTER PERIPHERAL NEURECTOMY

• Type: Another Publication in an International Scientific Journal
• Date: 1993

Authors

Castro-Lopes J.M. (Author) FMUP; Isaura Tavares (Author) FMUP; COIMBRA, A (Author) Other

Journal

Title: Brain Research

Vol. 620

Pages: 287-291

ISSN: 0006-8993

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 209 Citations

Scopus - 227 Citations

Other information

Authenticus ID: P-001-MRK

DOI: 10.1016/0006-8993(93)90167-l

Abstract (EN): A significant fall in the number of GABA-immunoreactive cells in laminae I-III of the rat spinal cord occurred in the somatotopic area of projection of the sciatic nerve after nerve transection. The decrease started at 2 weeks post-neurectomy, and at 4 weeks ipsilateral mean cell numbers were approximately 72% of contralateral control values. Similarly, the concentration of GABA in spinal homogenates was significantly reduced 4 weeks post-neurectomy. These data, together with our recent finding of an increase in spinal GABA during chronic inflammation of the hindlimb, suggest that the level of GABA in the dorsal horn is regulated by the amount of primary afferent input.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5