Preparation and characterisation of calcium-phosphate porous microspheres with a uniform size for biomedical applications

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Ribeiro, CC (Author) Other; Barrias, CC (Author) Other; Mário Adolfo Barbosa (Author) FEUP

Journal

Title: Journal of Materials Science: Materials in Medicine

Vol. 17

Pages: 455-463

ISSN: 0957-4530

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 49 Citations

Scopus - 51 Citations

Other information

Authenticus ID: P-004-M0N

DOI: 10.1007/s10856-006-8473-x

Abstract (EN): In the present work, a novel route for the preparation of porous ceramic microspheres is described. Two ceramic powders, calcillm-titanium-phosphate (CTP) and hydroxyapatite (HAp), were mixed with a sodium alginate solution that enabled the preparation of spherical particles, using the droplet extrusion method combined with ionotropic gelation in the presence of Ca2+. The spherical particles were Subsequently sintered, to burn-off the polymer and obtain calcium-phosphate microspheres with a uniform size and an interconnected porous network. CTP microspheres with diameters ranging from 513 +/- 24 mu m to 792 +/- 35 mu m and with pores of approximately 40 mu m were obtained. HAp microspheres presented diameters of 429 +/- 46 mu m and 632 40 +/- mu m and pores of ca. 2 mu m. Depending on the formulations tested, the structure of both calcium phosphates may become altered during the sintering process, suggesting that the ratio between the ceramic phase and the polymer Solution is a critical parameter. Porous microspheres prepared using the described methodology are promising candidates as bone defect fillers and scaffolds for bone tissue regeneration.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9