A novel urethane containing copolymer as a surface modification additive for blood contact materials

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Ji, J (Author) Other; Mário Adolfo Barbosa (Author) FEUP; Feng, LX (Author) Other; Shen, JC (Author) Other

Journal

Title: Journal of Materials Science: Materials in Medicine

Vol. 13

Pages: 677-684

ISSN: 0957-4530

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-000-NW2

DOI: 10.1023/a:1015789726455

Abstract (EN): Surface modification to develop a biomolecules-presenting surface is of interest, both from a scientific and an industrial point of view. In this research, a penta-block-coupling polymer of warfarin-PEO-MDI-PEO-warfarin was specially designed as the surface modifying additive (SMA). The warfarin-modified polyurethane surfaces were then prepared by dip-coating method. Attenuated total reflection fourier transform infra-red (ATR-FTIR) spectra revealed that the urethane segments in the SMA could penetrate into the hard block of segmented polyurethane (SPU) via intermolecular hydrogen bonds. The X-ray photoelectron spectroscopy (XPS) results indicated that the intermolecular hydrogen bonds were strong enough to form stable warfarin-PEO composite surfaces in an aqueous environment. Fibrinogen and albumin adsorption onto unmodified and SMA-modified SPU was investigated by the (1)25I-labeled method. The surface for attracting and reversibly binding albumin, which was proved to suppress the platelet adhesion and prolong the clotting time, has been developed by the simple coating of the novel SMA in SPU. (C) 2002 Kluwer Academic Publishers.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8