Effect of calcium phosphate addition to alginate microspheres: Modulation of enzyme release kinetics and improvement of cell adhesion

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Barrias, CC (Author) Other; Ribeiro, CC (Author) Other; Rodrigues, D (Author) Other; Miranda, MCS (Author) Other; Mário Adolfo Barbosa (Author) FEUP

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 5 Citations

Other information

Authenticus ID: P-000-58G

Abstract (EN): In this study, the addition of calcium phosphate powders to an alginate matrix was evaluated as a strategy to modulate enzyme release-kinetics from alginate microspheres and, simultaneously, to improve cell adhesion to the polymer. Pre-adsorption of the enzyme to the ceramic powders resulted in a more adequate release pattern. The ratio of ceramic-to-polymer had a pronounced effect on osteoblast adhesion to microspheres. Cells were only able to spread on microspheres with the highest percentage of ceramic (0.4 w/w using a 1.5% w/v alginate solution).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4